| Acronym | Meaning |
| ACL | Access Control List |
| ACL | Accelerator Command Language |
| ACL | Acquisition Career Level |
| ACL | Administration for Community Living (Office of Healthcare Information and Counseling) |
| ACL | Administrative Civil Liability (California) |
| ACL | Advanced Computer Laboratory |
| ACL | Advanced Concepts Laboratory |
| ACL | Aeronautical Computer Laboratory |
| ACL | Air Cadet League (of Canada) |
| ACL | Air Control Level (US DoD) |
| ACL | Aircraft Logbook |
| ACL | Allowable Cabin Load |
| ACL | Allowable Cargo Load |
| ACL | Allowable Combat Load |
| ACL | Allowance Components List |
| ACL | Annuaire des Collectivités Locales (French: Directory of Local Government) |
| ACL | Anti-Corruption Law (various locations) |
| ACL | Applied Chemistry Lab |
| ACL | Archives Centrales et Laboratoires (French: Central Archives and Laboratories; Royal Institute of Cultural Heritage; Belgium) |
| ACL | Area Control List (exports) |
| ACL | Automatic Carrier Landing |
| ACL | Automatic Clutter Mapping |