| Acronym | Meaning |
| SPAM | Spiced Ham (Hormel canned pork developed in 1937) |
| SPAM | Search Pattern Assessment Model |
| SPAM | Self Protection Analysis Model |
| SPAM | Shelter, Portable, Air Mobile |
| SPAM | Shelter, Protective, Aircraft Maintenance |
| SPAM | State Police Association of Massachusetts |
| SPAM | Stop Pornography and Abusive Marketing Act |
| SPAM | Strike Package and Associated Messages (tactical Tomahawk weapon control system) |
| SPAM | Survey Processing and Management |